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KMID : 0383819660130020005
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Tuberculosis and Respiratory Diseases
1966 Volume.13 No. 2 p.5 ~ p.8
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THE MINIMAL INHIBITORY CONCENTRATIONS OF ETHIONAMIDE AND CYCLOSERINE TO THE TUBERCLE BACILLI
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송호성(宋浩星)/Ho Sung Song
홍영표(洪永杓)/정인성(鄭寅聖)/조재승(趙載承)/Young Pyo Hong/In Sung Jung/Jae Sung Cho
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Abstract
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The minimal inhibitory concentrations of ethionamide and cycloserine to H37Rv strain
and wild strains in Youman´s media are increasing stepwise as the incubation time
pass. One of the cause of this phenomenon might be owing to the progressive decrease
of effective drug concentrations contained in the media.
The minimal inhibitory concentrations of ethionamide and cycloserine in H37Rv strain
are 0.8mcg/㎖ and 6mcg/㎖ respectively. In wild strains, the minimal inhibitory
concentrations of ethionamide are ranged from 0.4mcg/㎖ to 2.0mcg/㎖ in 85 strains, and
that of cyclose. rine are from below 5mcg/㎖ to 10mcg/㎖ in 106 strains by Youman´s
media at 10th incubation day.
On 4th incubation day microscopy is done, the evidence of growing of cells are judged
by cord formed and increased tubercle bacilli, when inocula are made with individually
seperated cells. As comparing with the turbidity on 10th day, above mentioned
microscopic findings are identical, the early detection of resistance to these two drugs
seems feasible and practicable.
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KEYWORD
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